Stephen Safe's lab reported that coffee's polyphenols, more than its caffeine, switch on a cellular stress-defense receptor. Every experiment ran in a dish, and the anti-aging headline traveled a great deal further than the data.
Up to 400 mg a day, roughly three to five cups of regular black coffee, is generally safe for most adults and may be linked to lower cardiovascular risk. The concentrated shot in the gym-bag can is a different animal, and the reason isn't the caffeine.
The compound reversed severe fatty liver in monkeys by starving one ammonia-making gut bacterium. It also comes from a company its lead inventor founded, and no human has taken it for this.
Brain & AgingTau is the new headliner at the Alzheimer's conference, but the anti-tau antibodies keep proving they bind the protein while doing nothing for patients. The clearest win so far is a blood test.
Metabolic & WeightUSC mice on a low-protein, methionine-tuned diet ate as many calories as the junk-food group and still lost fat, while their own bodies pumped out more GLP-1. The scientist behind it also owns the company selling longevity diets.
InvestigationsThe Partnership for Safe Medicines has deep ties to the drug lobby. Now it's urging the FDA to permanently block BPC-157, MOTS-c and five other off-patent peptides that compounding pharmacies sell cheap.
Autoimmune & InflammationFeed a rat plenty of fiber and a harmless tapeworm reaches full size and quiets the immune system. Cut the fiber to Western levels and the same worm shrinks, stops reproducing, and its anti-inflammatory power switches off.
Drugs & FDAUniversity at Buffalo chemists swapped harsh UV for a soft blue LED and got something the old chemistry rarely gives: two modifications to a molecule from a single reaction step.
Brain & AgingAmsterdam researchers scanned 110 women and found each pregnancy leaves its own mark, and the brain changes tied to maternal depression showed up months earlier the second time around.
Brain & AgingIt clips onto a 7-tesla scanner a hospital already owns, draws no extra power, and lifted the signal inside a living human eye by up to half.