neutrophils
3 stories tagged "neutrophils"
Cancer
Fused Into One Cell, a Neutrophil and a Macrophage Ate Tumors Two Ways
CAR-macrophage therapy keeps stalling in solid tumors: it can't get in, and it can't finish. Fuse a neutrophil onto it and, in mice, one dose shrank the tumor and kept it from coming back.
Infectious DiseaseIn Tuberculosis, the Cell We Called 'Neutral' Is the One Torching the Lung
In the people whose latent TB roared into active disease, the airways filled with neutrophils, half of them flipping on an interferon alarm, while their T cells were pushed to exhaustion and death.
Infectious DiseaseMost People's Bodies Quietly Beat TB. The Ones Who Lose Are Drowning Their Own T Cells.
A new single-cell study of the airways of TB-exposed people finds that progression to disease tracks with a neutrophil flood that smothers protective T cells, with type I interferon as the switch.